神戸大学附属図書館デジタルアーカイブ
https://hdl.handle.net/20.500.14094/E0001024

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メタデータID
E0001024
アクセス権
open access
出版タイプ
Version of Record
タイトル
Glutamate-induced Currents in Acutely Dissociated Guinea Pig Locus Coeruleus Neurons
Glutamate-induced Currents in Acutely Dissociated Guinea Pig Locus Coeruleus Neurons
著者
Sengoku, Atsushi ; Mori, Masahiro ; Okada, Yasuhiro ; Kamidono, Sadao
著者名
Sengoku, Atsushi
仙石, 淳
センゴク, アツシ
著者名
Mori, Masahiro
森, 正弘
モリ, マサヒロ
著者名
Okada, Yasuhiro
岡田, 安弘
オカダ, ヤスヒロ
著者名
Kamidono, Sadao
守殿, 貞夫
カミドノ, サダオ
言語
English (英語)
収録物名
The Kobe journal of the medical sciences
巻(号)
45(2)
ページ
85-92
刊行日
1999-04
抄録
To investigate the properties of L-glutamate (Glu) receptors in single locus coeruleus (LC) neurons at mature stage, we recorded the Glu-induced currents in the LC neurons acutely dissociated from adult guinea pigs, using the whole-cell patch-clamp technique. The concentration-current relationships show that Glu-induced currents in LC neurons might be predominantly mediated by non-NMDA receptors rather than NMDA receptors. The current-voltage relationship of NMDA or non-NMDA receptor-mediated currents indicated that both subtypes of the Glu-receptors operate non-selective cation channels, and that the NMDA receptor-operated channels but not the non-NMDA receptor-operated channels are permeable to Ca2+. These results suggest that in LC neurons, the normal excitatory neurotransmission may be mediated through non-NMDA receptors, and that NMDA receptors may be involved in intracellular signal transduction by their Ca2+ permeability.
カテゴリ
The Kobe journal of the medical sciences ＞ 45巻 ＞ 45巻2号（1999-04）
紀要論文