E0029600

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Not Applicable (or Unknown)

ハイガン ホウシャセン チリョウ カンジャ ノ シュヨウ キョクショ メンエキ ドウタイ ノ ケンキュウ

Clinical study of the histologic host response of the patients with lung cancer during radiotherapy

Japanese (日本語)

Medical journal of Kobe University

46(2)

41-49

1984-12

Serial bronchofiberscopic biopsies were performed during radiotherapy in 28 patients with squamous cell carcinoma of the lung. The effect of radiotherapy on tumor tissue was examined histologically as to the responsiveness of the host against tumor cells. The mononuclear cell infiltration induced in the tumor by irradiation correlated well with its direct effect on the tumor cells. The most remarkable infiltration was observed at the dose of 2000 rad and in the polypoid type. Indirect immunofluonescent technique with monoclonal anti OKT3 and OKIa revealed that most of the infiltrated cells were T-lymphocytes. There was a good relationship between the grade of mononuclear cell infiltration and the survival period. These facts suggest that the mononuclear cells in the irradiated turnor tissues represent host resistance against cancer and the intensity of the infiltration correlates with the clinical course and prognosis of the lung cancer patients.

T-lymphocyte

紀要論文