E0030128

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Not Applicable (or Unknown)

C-ペプタイド ソクテイ ノ リンショウテキ オウヨウ ニカンスル ケンキュウ

Clinical application of C-peptide measurement

Japanese (日本語)

Medical journal of Kobe University

45(1)

203-212

1984-01

In order to clarify the clincal significancance of C-peptide (CPR) measurement, IRI and CPR in blood was measured in normal subjects, diabetics and patients with insulin autoimmune syndrome and insulin-producing tumor under various conditions. Some of the serum and tissue extracts were fractionated by gel filtration to measure CPR in fractions corresponding to proinsulin and CPR in an attempts to measure proinsulin and C-peptide separately. Following results were obtained. (1) In normal subjects, CPR and insulin were secreted on equimolar basis in response to various stimuli. Disappearance of CPR from blood was definitely slower than insulin and this explained the absence of biphasic response of CPR to arginine and glucagon, unlike insulin. (2) In diabetics, CPR increased in oral glucose tolerance test like insulin, suggesting the usefulness of CPR as an index of secretory activity of pancreatic B cells instead of insulin, especially during insulin treatment. (3) Separate measurement of proinsulin and CPR revealed mainly proinsulin in blood of a patient with insulin autoimmune syndrome. In 5 of 6 patients with insulin-producing tumor, CPR was dominant both in the blood and tumor tissue. (4) In blood and tumor tissue of patients with insulin-producing tumor, peptides smaller than CPR were measured by radioimmunoassay, suggesting CPR heterogeneity. CPR radioimmunoassay thus appears to be clinically useful in providing information on pancreatic B cell function and pathophysiology of abnormal sugar metabolism.

insulin-producing tumor

紀要論文