神戸大学附属図書館デジタルアーカイブ
https://hdl.handle.net/20.500.14094/E0030326

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メタデータID
E0030326
アクセス権
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出版タイプ
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タイトル
ビタミンDの副甲状腺ホルモン-腎受容体系に及ぼす効果に関する研究 : 副甲状腺機能低下症の病態解析の面から
ビタミン D ノ コウジョウセン ホルモン ジン ジュヨウタイケイ ニオヨボス コウカ ニカンスル ケンキュウ フクコウジョウセン キノウ テイカショウ ノ ビョウタイ カイセキ ノ メンカラ
その他のタイトル
The study of vitamin D effects on parathyroid hormone-renal adenylate cyclase system : analysis of pathophysiology of hypoparathyroidism
著者
著者名
関, 温
Seki, Atsushi
セキ, アツシ
所属機関名
神戸大学医学部小児科学教室
言語
Japanese (日本語)
収録物名
神戸大学医学部紀要
Medical journal of Kobe University
巻(号)
44(2)
ページ
175-182
刊行日
1983-06
抄録
In order to assess the interaction between parathyroid hormone (PTH) and vitamin D_3 metabolites on the hormone receptor renal adenylate cyclase system, renal tissue samples obtained from wister rats were examined for the c-AMP content. Renal c-AMP content was measured by the competitive protein binding assay, and compared before and after the intravenous administrations of PTH, 1α(OH)D_3 1,25(OH)_2D_3 and these various combinations in normal and vitamin D deficient female wister rats. The results were as follows : 1) The c-AMP content of normal renal tissue increased 1.85 times one minutes after the administration of PTH. 2) The c-AMP content of normal renal tissue showed no increase after the loading of 1α(OH)D_3 or 1.25(OH)_2D_3. It responded to PTH 60 minutes after the 1α(OH)D_3 pretreatment, and its increasing ratio 1.92 was almost as same as that of PTH alone administrated. 3) The renal c-AMP content of vitamin D deficient rat showed no increase 1 minutes after the administration of PTH alone. (Increasing ratio was 1.10), but it showed some response 1 minutes after 1,25(OH)_2D_3 was given. (Increasing ratio was 1.43). 4) The renal c-AMP content of vitamin D deficient rat showed as same increase to PTH administration 60 minutes after the pretreatment of 1α(OH)D_3, and 5 minutes of 1,25(OH)_2D_3 as noted with PTH alone in normal kidney. (Increasing ratio was 1.74 and 2.12). These findings suggest that vitamin D does not enhance the reactivity of renal adenylate cyclase to PTH in normal rat, but in the vitamin D deficiency, renal adenylate cyclase little respond to PTH, though its reactivity come to restore after the vitamin D deficiency was corrected by administrating vitamin D_3 metabolites.
キーワード
vitamin D
PTH
hypoparathyroidism
adenylate cyclase
C-AMP
カテゴリ
紀要論文