神戸大学附属図書館デジタルアーカイブ
https://hdl.handle.net/20.500.14094/E0030464

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メタデータID
E0030464
アクセス権
metadata only access
出版タイプ
Not Applicable (or Unknown)
タイトル
卵巣のblood-follicle barrier
ランソウ ノ blood-follicle barrier
その他のタイトル
Effects of gonadotropins, steroid hormones and histamine the blood-follicle barrier of the ovary
著者
著者名
和田, 裕充
Wada, Hiromitsu
ワダ, ヒロミツ
所属機関名
神戸大学医学部産科婦人科学教室
言語
Japanese (日本語)
収録物名
神戸大学医学部紀要
Medical journal of Kobe University
巻(号)
42(2)
ページ
615-623
刊行日
1981-02
抄録
Effects of gonadotropins (pregnant mare serum gonadotropin: PMS, human chorionic gonadotropin : HCG), steroid hormones (estradiol, progesterone) and histamine on permeability in the bloodfollicle barrier were studied in Japanese female white rabbits. PMS(300 IU) was administered through the marginal ear vein and 9 hours later 200 μCi of <131>^I-labeled human serum albumin (RISA) was administered intravenously. Ovaries were excised 9.5 hours after PMS injection and blood samples were collected from the abdominal aorta. Follicular fluid was aspirated from large antral follicles. And the transfer rate [follicular fluid (c. p. m.)
serum (c. p. m.) ] was examined. The average transfer rate in the control group was 45.3%. When PMS (1000 IU) or HCG (1000 IU) was administered after 8.5 hours following the first PMS injection, the average transfer rates became 52.3% (not significant : n. s.) in PMS group and 56.1% (p<0.05) in HCG group. When estradiol (10mg) or progesterone (100mg) was injected sukutaneously after 7 hours following the first PMS injection, the average transfer rates became 55.9%(p<0.05) in estradiol group and 50.2%(n. s.) in progesterone group. Moreover, continuous infusion of 10ml saline alone or 500μg histamine dissolved in 10ml saline was also done through the catheter to the renal artery from 8 hours 55 minutes to 9 hours 30 minutes after the first PMS injection. The average transfer rate in histamine group (50.9%) became significantly (p<0.01) higher than that of saline control group (41.9%). HCG group, estradiol group and histamine group showedhistologically the marked dilatation of the perifollicular blood vessels, especially thecal capillaries just beneath the granulosa layer. In contrast, PMS group and progesterone group did not show any obvious difference as compared with the control group. These results may indicate that HCG, estradiol and histamine increase the permeability in the blood-follicle barrier with the dilatation of the perifollicular blood vessels although PMS and progesterone do not.
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紀要論文