E0030471

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thyrotropin releasing hormone フカ シケン ノ ヒョウジュンカ ニカンスル リンショウテキ ケンキュウ

Clinical study of standardization for thyrotropin releasing hormone test

Japanese (日本語)

Medical journal of Kobe University

42(3)

693-703

1981-10

Clinical observation was carried out as to the affecting factors and other respects to which due attention should be paid in TRH test and obtained following results for standardization. 1) The acetate displayed stronger TSH releasing action than TRH tartrate and TRH free. 2) In aged subjects the mean value of plasma TSH response was lower than that of younger ones in both sexes. 3) In puberty, the presence of individuals showing larger TSH response to TRH was suggested. 4) By a dose of TRH less than 200μg, females tended to show relatively larger TSH response in comparison with males. 5) In the female sexual cycle TSH response to TRH 100μg tended to be larger in the follicular period than in the luteal period. 6) As for the dose, an almost maximum increase in TSH was registered with TRH 400μg. 7) The consecutive administration of TRH for 3 days resulted in the registration of a smaller TSH response on the 3rd day in comparison with the 1st day. 8) Following the initial administration, TSH was given 3, 5 and 7 days later, and a TSH response almost equivalent to the same marked by the initial administration was registered on the 7th day. Therefore, it is reasonable that interval of repeating TRH test needs 2 weeks. 9) In patients with chronic renal failure, TSH response tended to be low. 10) In patients with chronic hepatitis and liver cirrhosis, the basal TSH was high in general, presenting an excessive response and a delay in recovery to the previous value in some cases. 11) In the daytime, plasma TSH tended to remain low in comparison with the same at nighttime. From these results, affecting facrors for evaluation of TRH test were examined. Above findings should be considerable for standardization of TRH test.

Interval of administration

紀要論文